| Ralph Fregosi | ||
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Professor Ph.D. University of Wisconsin-Madison 1985 |
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| Office: | 93 Gittings 119c | |
| Email: | fregosi@u.arizona.edu | |
| Phone: | (520) 621-2203 | |
| Fax: | (520) 621-**** | |
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The goal of our research is to understand how the nervous system controls the muscles of breathing. Under this umbrella, our studies are divided into three main areas:
1. We are interested in the role of inhibitory and excitatory neurotransmission in respiratory rhythm generation. Specifically, how these receptors are altered throughout development, and with prenatal nicotine exposure; these studies relate directly to neonatal breathing instability, including the Sudden Infant Death Syndrome (SIDS). Studies are done using the in vitro brain stem spinal cord preparation of neonatal rat, and are buttressed by parallel in vivo studies. 2. Neural control of “upper airway muscles”. These muscles line the external nares, the pharynx and the larynx, and are innervated by cranial nerves. Upper airway muscles control the resistance to airflow through the nasal, pharyngeal and laryngeal airways, which are responsible for regulating airflow resistance; malfunction of these muscles is implicated in diseases such as sleep apnea. 3. Neural control of breathing and pharyngeal geometry in children with sleep disordered breathing.
Selected Recent Publications Bailey EF Huang YH Fregosi RF. Nov 2006. Anatomic consequences of intrinsic tongue muscle activation. J Appl Physiol, 101:1377-85 Fregosi RF Quan SF Morgan WL Goodwin JL Cabrera R Shareif I Fridel KW Bootzin RR. Sep 2006. Pharyngeal critical pressure in children with mild sleep-disordered breathing. J Appl Physiol, 101:734-9 Bailey EF Fregosi RF. Aug 2006. Modulation of upper airway muscle activities by bronchopulmonary afferents. J Appl Physiol, 101:609-17 Fregosi RF, Quan SF. Dec 2005. MRI of pharyngeal airway in children with sleep-disordered breathing. J Appl Physiol, 99:2470; author reply 2 John J, Bailey EF, Fregosi RF. Sep 2005. Respiratory Related Discharge of Genioglossus Muscle Motor Units. Am J Respir Crit Care Med,2005 Sep 1; Bailey EF, Janssen PL, Fregosi RF. Mar 2005. PO2 Dependent Changes in Intrinsic and Extrinsic Tongue Muscle Activities in the Rat. Am J Respir Crit Care Med,2005 Mar 18; Luo Z, Costy-Bennett S, Fregosi RF. Dec 2004. Prenatal nicotine exposure increases the strength of GABAA receptor-mediated inhibition of respiratory rhythm in neonatal rats. J Physiol, 561:387-93 Displaying 1 - 7 of 59
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